Hye Won Kang

Research Interests

My research interest is to find a novel way to prevent obesity by activating brown fat and browning white fat using dietary compounds at molecular biological and physiological levels using mice and mammalian cell models. This includes (1) identification of dietary compounds which activate brown fat, (2) finding a mechanism by which dietary compounds activate brown fat and browning effect on white fat, (3) understanding a relationship between brown fat and other oxidative tissues to prevent obesity.

Recent Publications

• Inah Gu, Olugbenga Balogun , Cindi Brownmiller , Hye Won Kang, Sun-Ok Lee (2023). (Bioavailability of citrulline in watermelon flesh, rind, and skin using a human intestinal epithelial Caco-2 cell model). (8) 13, pp. 4882. Appl. Sci.
• Olugbenga Balogun, Dammah Otieno, Cindi Brownmiller, Sun-Ok Lee, Hye Won Kang (2022). (Effect of watermelon (Citrullus lanatus) extract on carbohydrates-hydrolyzing enzymes in vitro). (6) 12, pp. 772. Agriculture.
• Olugbenga Balogun, Hye Won Kang (2022). (Garlic scape (Allium sativum L.) extract decreases adipogenesis by activating AMK-activated protein kinase during the differentiation in 3T3-L1 adipocytes). (1) 25, pp. 24-32. Journal of Medicinal Food.
• Ya Pei, Olugbenga Balogun, Dammah Otieno, John Parks, Hye Won Kang (2022). (The effects of brewers’ spent grain on high-fat diet-induced fatty liver). 616, pp. 49-55. Biochemical and Biophysical Research Communications.
• Ya Pei, Dammah Otieno, Inah Gu, Sun-Ok Lee,, John Parks, Keith Schimmel, Hye Won Kang (2021). (Effect of quercetin on non-shivering thermogenesis of brown adipose tissue in high-fat diet-induced obese mice). 88, pp. 108532. The Journal of Nutritional Biochemistry.
• Ya Pei, John Parks, Hye Won Kang (2021). (Quercetin alleviates high-fat diet-induced inflammation in brown adipose tissue). 95, pp. 104614. Journal of Functional Foods.
• Sang Gil Lee, Cindi Brownmiller, Sun-Ok Lee , Hye Won Kang (2020). (Anti-inflammatory and antioxidant effects of anthocyanins of Trifolium pratense (red clover) in lipopolysaccharide-stimulated RAW-267.4 macrophages). (4) 12, pp. 1089. Nutrients.
• Dammah Otieno, Eun-Joung Lee, Sang Lee, Courtney Richard, Hye Won Kang (2020). (Optimizing process of brewing onion peel tea using response surface methodology). NFS Journal.
• Emmanuel Asiamah, Mario Vailati-Riboni, Juan Loor, Worku Mulumebet, Hye Won Kang (2020). (Supplemental methionine, choline, or affect galectin gene expression in adult holstein cow and neonatal holsein calf neutrophils in vitro). (1) 10, pp. 87-92. Journal of Microbiology, Biotechnology and Food Sciences .
• Hye Won Kang, Sung Jin Lee, Jane Walker (2018). (Assessing breakfast eating behaviors of historically Black College and University (HBCU) students). (2) 110, pp. 43-48. Journal of Family and Consumer Sciences.
• Hye Won Kang, Sang Lee, Dammah Otieno, Kyoungsoo Ha (2018). (Flavonoids, potential bioactive compounds and non-shivering thermogenesis.). (9) 10, pp. 1168. Nutrients.
• Hye Won Kang, Won-Chul Lim, Jin-Kyu Lee, Jin-Nyoung Ho, Eun-Jeong Lim, Hong-Yon Cho (2017). (Germinated Waxy Black Rice Ameliorates Hyperglycemia and Dyslipidemia in Streptozotocin-Induced Diabetic Rats). (11) 40, pp. 1846-1855. Biological and Pharmaceutical Bulletin.
• Jae-Woo Choi, Hye Won Kang, Won-Chul Lim, Mi-Kyoung Kim, In-Young Lee, Hong-Yon Cho (2017). (Kefir Prevented Excess Fat Accumulation in Diet-Induced Obese Mice). (5) 81, pp. 958-965 . Bioscience, Biotechnology, and Biochemistry.
• Sang Gil Lee, John Parks, Hye Won Kang (2017). (Quercetin, a functional compound of onion peel, remodels white adipocytes to brown-like adipocytes). 42, pp. 62-71. The Journal of Nutritional Biochemistry.
• Eun-Jin Jung, Young-Suk Kim, Jung-Wa Choi, Hye Won Kang, Un-Jae Chang (2017). (The Analysis of a Diet for the Human Being and the Companion Animal using Big Data in 2016). (4) 6, pp. 256-266. Clinical Nutrition Research.
• Ragina Rafiq, Saeed Hayek, Ugochukwu Anyanwu, Bonita Hardy, Valerie Giddings, Salam Ibrahim, Reza Tahergorabi, Hye Won Kang (2016). (Antibacterial and Antioxidant Activities of Essential Oils from Artemisia herba-alba Asso., Pelargonium capitatum x radens and Laurus nobilis L.). (2) 5, pp. 28. Foods.
• Hye Won Kang (2016). (Can eating foods burn body fat?). (1) 2016, pp. 1. Journal of Obesity and Nutritional Disorders.
• Sang Gil Lee, Joanna Siaw, Hye Won Kang (2016). (Stimulatory Effects of Cinnamon Extract (Cinnamomum cassia) during the Initiation Stage of 3T3-L1 Adipocyte Differentiation). (83) 5, pp. 1-9. Foods.
• Valeriy Demchev, Geraldine Malana, Divya Vangala, Janis Stoll, Anal Desai, Hye Won Kang, Yingxia Li, Hamed Nayeb-Hashemi, Michele Niepel, David Cohen, Chinweike Ukomadu (2013). (Targeted deletion of fibrinogen like protein 1 reveals a novel role in energy substrate utilization). (3) 8, pp. e58084. PLoS ONE.
• Hye Won Kang, Cafer Ozdemir, Yuki Kawano, Katherine LeClair, Cecile Vernochet, Ronald Kahn, Susan Hagen, David Cohen (2013). (Thioesterase superfamily member 2/acyl-CoA thioesterase 13 (Them2/Acot13) regulates adaptive thermogenesis in mice). (46) 288, pp. 33376-33386. J Biol Chem.
• Hye Won Kang, Michele Niepel, Shuxin Han, Yuki Kawano, David Cohen (2012). (Thioesterase superfamily member 2 (Them2)/Acyl-CoA thioesterase 13 (Acot13) regulates hepatic lipid and glucose metabolism). (5) 26, pp. 2209-2221. FASEB J.
• Melany Castillo, Jessica Hall, Mayrin Correa-Medina, Cintia Ueta, Hye Won Kang, David Cohen, Antonio Bianco (2011). (Disruption of thyroid hormone activation in Type 2 deiodinase knockout mice causes obesity with glucose intolerance and liver steatosis only at thermoneutrality.). (4) 60, pp. 1082-1089. Diabetes.
• Hye Won Kang, Jie Wei, David Cohen (2010). (PC-TP/StARD2: Of membranes and metabolism. ). (7) 21, pp. 449-456. Trends Endocrinol Metab .
• Hye Won Kang, Keishi Kanno, Erez Scapa, David Cohen (2010). (Regulatory role for phosphatidylcholine transfer protein/StarD2 in the metabolic response to peroxisome proliferator activated receptor alpha (PPARα). ). (4) 1801, pp. 496-502. Biochim Biophys Acta .
• Hye Won Kang, Scott Ribich, Brian Kim, Susan Hagen, Antonio Bianco, David Cohen (2009). (Mice lacking phosphatidylcholine transfer protein/StarD2 exhibit increased adaptive thermogenesis and enlarged mitochondria in brown adipose tissue.). (11) 50, pp. 2212-2221. J Lipid Res .
• Jie Wei, Hye Won Kang, David Cohen (2009). (Thioesterase superfamily member 2 (Them2)/Acyl-CoA thioesterase 13 (Acot13): A homotetrameric hotdog fold thioesterase with selectivity for long chain fatty acyl-CoAs.). (2) 421, pp. 311-322. Biochem J .
• Hye Won Kang, Bhimidi, Brun, Fernandez, McGrane, (2007). (Altered lipid catabolism in the vitamin A deficient liver). (1-2) 271, pp. 18-27. Mol Cell Endocrinol .
• Hye Won Kang, Kwang won Yu, Woo Jin Chun, Ih Seop Chang, Sang Bae Han, Hee Yun Kim, Hong Yon Cho (2002). (Isolation and Characterization of alkyl peroxy radical scavenging compound from leaves of Laurus nobilis. ). (1) 25, pp. 102-108. Biol Pharm Bull .