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Robert H Newman

Associate Professor

North Carolina Agricultural and Technical State University
Contact
Barnes Hall 105
Education
Ph.D.Biochemistry and Molecular Biology / Johns Hopkins University
B.A.Biology and Biochemistry / McDaniel College

Research Interests

We are interested in understanding the regulation of phosphorylation-dependent signaling pathways. Research is organized around two central questions: 1) which cellular proteins are phosphorylated by a given kinase and 2) how are specific kinases and phosphatases—and ultimately the signaling networks of which they are a part—regulated within the cellular environment? To answer these questions, we take a two-pronged approach based on 1) systems-level analysis of kinase-substrate relationships and the biochemical factors underlying kinase substrate selection and 2) the development and application of genetically-targetable FRET-based biosensors.

Recent Publications

  • Robert Newman, Roy Coomans, Checo Rorie, , Mary Smith, Angela White, Kelsie Bernot, Cailisha Petty, Catherine White, Grace Byfield (2019). (A Transformative Approach to Advising STEM Students at an HBCU Mary A. Smith, An). (Diversity in Higher Education) 22, pp. 291-316 ). Emerald Publishing Limited.
  • Lei Cao, Rashin Sedighi, Ava Boston, Lakmini Premadasa, Jamilla Pinder, George Crawford, Olugbemiga Jegede, Scott Harrison, Robert Newman, Elimelda Ongeri, , Lei Cao, Rashin Sedighi, Scott Harrison, Robert Newman (2018). (Undiagnosed kidney injury in uninsured and underinsured diabetic African American men and putative role of meprin metalloproteases in diabetic nephropathy). ). International Journal of Nephrology.
  • H Al-Barakati, E McConnell, L Hicks, L Poole, Robert Newman, Dukka Kc, Dukka Kc, H Al-Barakati, Robert Newman (2018). (SVM-SulfoSite: A support vector machine based predictor for sulfenylation sites.). (1) 8, pp. 11288 ). Scientific reports.
  • H Ismail, Robert Newman, Dukka Kc, Dukka Kc, Robert Newman, H Ismail (2016). (RF-Hydroxysite: a random forest based predictor for hydroxylation sites.). (8) 12, pp. 2427-35 ). Molecular bioSystems.
  • Jean-Marie Niyitegeka, Adam Bastidas, Robert Newman, Susan S.Taylor, Elimelda Ongeri, , Jean-Marie Niyitegeka, Elimelda Ongeri, Robert Newman (2015). (Isoform-specific interactions between meprin metalloproteases and the catalytic subunit of Protein Kinase A: Significance in acute and chronic kidney injury). (No) 308, pp. F56-F68 ). American Journal of Physiology - Renal.
  • Crystal Woodard, G Liao, Corey Goodwin, Jianfei Hu, T Dos Reis, Robert Newman, Heesool Rho, Jiang Qian, Heng Zhu, S Hayward, Crystal Woodard, Robert Newman (2015). (A Screen for ERK Primed GSK-3 Substrates Identifies the p53 Inhibitor iASPP). pub ahead of print, pp. pii: JVI.01072-15 ). J. Virol.
  • Akamu Ewunkem, Carl Parson, Perpetua Muganda, Robert Newman, Robert Newman, Perpetua Muganda, Akamu Ewunkem (2015). (A Low-Cost Method for Tracking the Induction of Apoptosis using FRET-based Activity Sensors in Suspension Cells). In PM Muganda, (Apoptosis) ). Methods in Toxicology/Humana Press.
  • Robert Newman, Jin Zhang, Jin Zhang, Robert Newman (2014). (The Design and Application of Genetically Encodable Biosensors Based on Fluorescent Proteins). (Fluorescent Protein-based Biosensors) 1071, pp. 16 ). Methods in Molecular Biology/Humana Press/Springer.
  • Robert Newman, Qiang Ni, Jin Zhang, Robert Newman, Qiang Ni (2014). (Fluorescent Protein-based Biosensors: Methods and Protocols). In Robert H. Newman, Qiang Ni, Jin Zhang, 1071, pp. 251 ). Methods in Molecular Biology/Humana Press/Springer.
  • Jianfei Hu, Hee-Sool Rho, Robert Newman, et al., Jianfei Hu, Robert Newman (2014). (PhosphoNetworks: a database for human phosphorylation networks). (1) 30, pp. 2 ). Bioinformatics.
  • X. Wu, S. Renuse, N. Sahasrabuddhe, M. Zahari, R. Chaerkady, M. Kim, Robert Newman, H. Zhu, B. Vogelstein, B. Park, A. Pandey, X. Wu, Robert Newman (2014). (Activation of diverse signaling pathways by oncogenic PIK3CA mutations). 5, pp. 4961-4989 ). Nature Communications.
  • Jianfei Hu, Hee-Sool Rho, Robert Newman, Woochang Hwang, et al., Jianfei Hu, Robert Newman (2014). (Global analysis of phosphorylation networks in humans). 1844, ). Biochemica Biophysica Acta-Proteins and Proteomics/Elsevier.
  • Crystal Woodard, G. Liao, Corey Goodwin, Jianfei Hu, Z. Xie, Robert Newman, T. dos Reis, et al., Crystal Woodard, Robert Newman (2013). (Profiling the dynamics of a human phosphorylome reveals new components in HGF/c-Met signaling). (9) 8, pp. 12 ). PLoS One.
  • Robert Newman, Jianfei Hu, Hee-Sool Rho, et al., Robert Newman, Jianfei Hu (2013). (Construction of human activity-based phosphorylation networks). (1) 9, pp. 12 ). Molecular Systems Biology/EMBO/Macmillan Publishing.
  • Crystal Woodard, Corey Goodwin, J. Wan, S. Xia, Jianfei Hu, Robert Newman, et al., Robert Newman, Crystal Woodard (2012). (Phosphorylation of the chromatin binding domain of KSHV LANA). (10) 8, pp. 12 ). PLoS Pathogens.
  • Mary Smith, Angela White, Kelsie Bernot, Cailisha Petty, Catherine White, Grace Byfield, Robert Newman, Roy Coomans, Checo Rorie, , , Roy Coomans, Robert Newman, Cailisha Petty, , Mary Smith, Grace Byfield, Checo Rorie, Catherine White, Angela White, Kelsie Bernot (A Transformative Approach to Advising STEM Students at an HBCU Mary A. Smith, An). (Diversity in Higher Education) ).
  • Lei Cao, Ava Boston, Olugbemiga Jegede, Scott Harrison, Robert Newman, Elimelda Ongeri, Lei Cao, Robert Newman, Elimelda Ongeri, Scott Harrison (Inflammation and kidney injury in diabetic African American men). (no) (https://www.ncbi.nlm.nih.gov/pubmed/30868076) 2019, pp. 2019 Feb 5;2019:5359635. doi: 10.1155/2019/5359635. eCollection 2019. ). Journal of diabetes research.
  • Robert Newman, Robert Newman (From Cellular Mechanisms to Physiological Responses: Functional Signal Integration Across Multiple Biological Levels ). In Richard Neubig and Jonathan Boyd, ). Wiley.