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Robert H Newman

Associate Professor

North Carolina Agricultural and Technical State University
College
College of Science and Technology

Department
Biology

Contact
Barnes Hall 105
Education
B.A.Biology and Biochemistry / McDaniel College
Ph.D.Biochemistry and Molecular Biology / Johns Hopkins University

Research Interests

We are interested in understanding the regulation of phosphorylation-dependent signaling pathways. Research is organized around two central questions: 1) which cellular proteins are phosphorylated by a given kinase and 2) how are specific kinases and phosphatases—and ultimately the signaling networks of which they are a part—regulated within the cellular environment? To answer these questions, we take a two-pronged approach based on 1) systems-level analysis of kinase-substrate relationships and the biochemical factors underlying kinase substrate selection and 2) the development and application of genetically-targetable FRET-based biosensors.

Recent Publications

  • Robert Newman, Kaushik Roy, Niraj Thapa (2020). (DeepSuccinylSite: a deep learning based approach for protein succinylation site prediction). (63) 21, ). BMC Bioinformatics.
  • Kelsie Bernot, Grace Byfield, Roy Coomans, Robert Newman, Cailisha Petty, Checo Rorie, Mary Smith, Angela White, Catherine White (2019). (A Transformative Approach to Advising STEM Students at an HBCU Mary A. Smith, An). (Diversity in Higher Education) 22, pp. 291-316 ). Emerald Publishing Limited.
  • Emmanuel Asiamah, Kingsley Ekwemalor, Robert Newman, Mulumebet Worku (2019). (Natural and synthetic pathogen associated molecular patterns modulate galectin expression in cow blood). (5) 61, pp. 245-253 ). JOURNAL OF ANIMAL SCIENCE AND TECHNOLOGY.
  • Ava Boston, Lei Cao, George Crawford, Scott Harrison, Olugbemiga Jegede, Robert Newman, Elimelda Ongeri, Jamilla Pinder, Lakmini Premadasa, Rashin Sedighi (2018). (Undiagnosed kidney injury in uninsured and underinsured diabetic African American men and putative role of meprin metalloproteases in diabetic nephropathy). ). International Journal of Nephrology.
  • H Al-Barakati, L Hicks, Dukka Kc, E McConnell, Robert Newman, L Poole (2018). (SVM-SulfoSite: A support vector machine based predictor for sulfenylation sites.). (1) 8, pp. 11288 ). Scientific reports.
  • H Ismail, Dukka Kc, Robert Newman (2016). (RF-Hydroxysite: a random forest based predictor for hydroxylation sites.). (8) 12, pp. 2427-35 ). Molecular bioSystems.
  • Adam Bastidas, , Susan S.Taylor, , Robert Newman, Jean-Marie Niyitegeka, Elimelda Ongeri (2015). (Isoform-specific interactions between meprin metalloproteases and the catalytic subunit of Protein Kinase A: Significance in acute and chronic kidney injury). 308, pp. F56-F68 ). American Journal of Physiology - Renal.
  • T Dos Reis, Corey Goodwin, S Hayward, Jianfei Hu, G Liao, Robert Newman, Jiang Qian, Heesool Rho, Crystal Woodard, Heng Zhu (2015). (A Screen for ERK Primed GSK-3 Substrates Identifies the p53 Inhibitor iASPP). pub ahead of print, pp. pii: JVI.01072-15 ). J. Virol.
  • Akamu Ewunkem, Perpetua Muganda, Robert Newman, Carl Parson (2015). (A Low-Cost Method for Tracking the Induction of Apoptosis using FRET-based Activity Sensors in Suspension Cells). In PM Muganda, (Apoptosis) ). Methods in Toxicology/Humana Press.
  • Robert Newman, Qiang Ni, Jin Zhang (2014). (Fluorescent Protein-based Biosensors: Methods and Protocols). In Robert H. Newman, Qiang Ni, Jin Zhang, 1071, pp. 251 ). Methods in Molecular Biology/Humana Press/Springer.
  • Robert Newman, Jin Zhang (2014). (The Design and Application of Genetically Encodable Biosensors Based on Fluorescent Proteins). (Fluorescent Protein-based Biosensors) 1071, pp. 16 ). Methods in Molecular Biology/Humana Press/Springer.
  • et al., Jianfei Hu, Robert Newman, Hee-Sool Rho (2014). (PhosphoNetworks: a database for human phosphorylation networks). (1) 30, pp. 2 ). Bioinformatics.
  • et al., Jianfei Hu, Woochang Hwang, Robert Newman, Hee-Sool Rho (2014). (Global analysis of phosphorylation networks in humans). 1844, ). Biochemica Biophysica Acta-Proteins and Proteomics/Elsevier.
  • R. Chaerkady, M. Kim, Robert Newman, A. Pandey, B. Park, S. Renuse, N. Sahasrabuddhe, B. Vogelstein, X. Wu, M. Zahari, H. Zhu (2014). (Activation of diverse signaling pathways by oncogenic PIK3CA mutations). 5, pp. 4961-4989 ). Nature Communications.
  • et al., Jianfei Hu, Robert Newman, Hee-Sool Rho (2013). (Construction of human activity-based phosphorylation networks). (1) 9, pp. 12 ). Molecular Systems Biology/EMBO/Macmillan Publishing.
  • et al., T. dos Reis, Corey Goodwin, Jianfei Hu, G. Liao, Robert Newman, Crystal Woodard, Z. Xie (2013). (Profiling the dynamics of a human phosphorylome reveals new components in HGF/c-Met signaling). (9) 8, pp. 12 ). PLoS One.
  • et al., Corey Goodwin, Jianfei Hu, Robert Newman, J. Wan, Crystal Woodard, S. Xia (2012). (Phosphorylation of the chromatin binding domain of KSHV LANA). (10) 8, pp. 12 ). PLoS Pathogens.
  • Robert Newman (From Cellular Mechanisms to Physiological Responses: Functional Signal Integration Across Multiple Biological Levels ). In Richard Neubig and Jonathan Boyd, ). Wiley.
  • Ava Boston, Lei Cao, Scott Harrison, Olugbemiga Jegede, Robert Newman, Elimelda Ongeri (Inflammation and kidney injury in diabetic African American men). (https://www.ncbi.nlm.nih.gov/pubmed/30868076) 2019, pp. 2019 Feb 5;2019:5359635. doi: 10.1155/2019/5359635. eCollection 2019. ). Journal of diabetes research.
  • Kelsie Bernot, Grace Byfield, Roy Coomans, Robert Newman, Cailisha Petty, Checo Rorie, Mary Smith, Angela White, Catherine White (A Transformative Approach to Advising STEM Students at an HBCU Mary A. Smith, An). (Diversity in Higher Education) ).