Robert H Newman

Research Interests

We are interested in understanding the regulation of phosphorylation-dependent signaling pathways. Research is organized around two central questions: 1) which cellular proteins are phosphorylated by a given kinase and 2) how are specific kinases and phosphatases—and ultimately the signaling networks of which they are a part—regulated within the cellular environment? To answer these questions, we take a two-pronged approach based on 1) systems-level analysis of kinase-substrate relationships and the biochemical factors underlying kinase substrate selection and 2) the development and application of genetically-targetable FRET-based biosensors.

Recent Publications

• Jeannette Delva-Wiley, Israt Jahan, Robert Newman, Lifeng Zhang, Ming Dong (2021). (Computational Analysis of the Binding Mechanism of GenX and HSA). 6, pp. 29166-29170. ACS Omega.
• M Shafei, T Forshaw, J Davis, A Flemban, D Qualtrough, S Dean, C Perks, Ming Dong, Robert Newman, M Conway (2020). (BCATc modulates crosstalk between the PI3K/Akt and the Ras/ERK pathway regulating proliferation in triple negative breast cancer.). (21) 11, pp. 1971-1987. Oncotarget.
• Niraj Thapa, Meenal Chaudhari, Sean McManus , Kaushik Roy, Robert Newman, Hiroto Saigo, Dukka KC (2020). (DeepSuccinylSite: a deep learning based approach for protein succinylation site prediction). (63) 21, BMC Bioinformatics.
• Hussam AL barakati, NIraj Thapa, Saigo Hiroto, Kaushik Roy, Robert Newman, Dukka KC (2020). (RF-MaloSite and DL-Malosite: Methods based on random forest and deep learning to identify malonylation sites). 18, pp. 852-860. Computational and Structural Biotechnology Journal.
• Mary Smith, Angela White, Kelsie Bernot, Cailisha Petty, Catherine White, Grace Byfield, Robert Newman, Roy Coomans, Checo Rorie, , (2019). (A Transformative Approach to Advising STEM Students at an HBCU Mary A. Smith, An). (Diversity in Higher Education) 22, pp. 291-316. Emerald Publishing Limited.
• Emmanuel Asiamah, Kingsley Ekwemalor, Sarah Adiel-Frema, Bertha Osei, Robert Newman, Mulumebet Worku (2019). (Natural and synthetic pathogen associated molecular patterns modulate galectin expression in cow blood). (5) 61, pp. 245-253. JOURNAL OF ANIMAL SCIENCE AND TECHNOLOGY.
• H Al-Barakati, E McConnell, L Hicks, L Poole, Robert Newman, Dukka Kc (2018). (SVM-SulfoSite: A support vector machine based predictor for sulfenylation sites.). (1) 8, pp. 11288. Scientific reports.
• Lei Cao, Rashin Sedighi, Ava Boston, Lakmini Premadasa, Jamilla Pinder, George Crawford, Olugbemiga Jegede, Scott Harrison, Robert Newman, Elimelda Ongeri, (2018). (Undiagnosed kidney injury in uninsured and underinsured diabetic African American men and putative role of meprin metalloproteases in diabetic nephropathy). International Journal of Nephrology.
• H Ismail, Robert Newman, Dukka Kc (2016). (RF-Hydroxysite: a random forest based predictor for hydroxylation sites.). (8) 12, pp. 2427-35. Molecular bioSystems.
• Akamu Ewunkem, Carl Parson, Perpetua Muganda, Robert Newman (2015). (A Low-Cost Method for Tracking the Induction of Apoptosis using FRET-based Activity Sensors in Suspension Cells). In PM Muganda, (Apoptosis) Methods in Toxicology/Humana Press.
• Crystal Woodard, G Liao, Corey Goodwin, Jianfei Hu, T Dos Reis, Robert Newman, Heesool Rho, Jiang Qian, Heng Zhu, S Hayward (2015). (A Screen for ERK Primed GSK-3 Substrates Identifies the p53 Inhibitor iASPP). pub ahead of print, pp. pii: JVI.01072-15. J. Virol.
• Jean-Marie Niyitegeka, Adam Bastidas , Robert Newman, Susan S.Taylor , Elimelda Ongeri, (2015). (Isoform-specific interactions between meprin metalloproteases and the catalytic subunit of Protein Kinase A: Significance in acute and chronic kidney injury). 308, pp. F56-F68. American Journal of Physiology - Renal.
• X. Wu, S. Renuse, N. Sahasrabuddhe, M. Zahari, R. Chaerkady, M. Kim, Robert Newman, H. Zhu, B. Vogelstein, B. Park, A. Pandey (2014). (Activation of diverse signaling pathways by oncogenic PIK3CA mutations). 5, pp. 4961-4989. Nature Communications.
• Robert Newman, Qiang Ni, Jin Zhang (2014). (Fluorescent Protein-based Biosensors: Methods and Protocols). In Robert H. Newman, Qiang Ni, Jin Zhang, 1071, pp. 251. Methods in Molecular Biology/Humana Press/Springer.
• Jianfei Hu, Hee-Sool Rho, Robert Newman, Woochang Hwang, et al. (2014). (Global analysis of phosphorylation networks in humans). 1844, Biochemica Biophysica Acta-Proteins and Proteomics/Elsevier.
• Jianfei Hu, Hee-Sool Rho, Robert Newman, et al. (2014). (PhosphoNetworks: a database for human phosphorylation networks). (1) 30, pp. 2. Bioinformatics.
• Robert Newman, Jin Zhang (2014). (The Design and Application of Genetically Encodable Biosensors Based on Fluorescent Proteins). (Fluorescent Protein-based Biosensors) 1071, pp. 16. Methods in Molecular Biology/Humana Press/Springer.
• Robert Newman, Jianfei Hu, Hee-Sool Rho, et al. (2013). (Construction of human activity-based phosphorylation networks). (1) 9, pp. 12. Molecular Systems Biology/EMBO/Macmillan Publishing.
• Crystal Woodard, G. Liao, Corey Goodwin, Jianfei Hu, Z. Xie, Robert Newman, T. dos Reis, et al. (2013). (Profiling the dynamics of a human phosphorylome reveals new components in HGF/c-Met signaling). (9) 8, pp. 12. PLoS One.
• Crystal Woodard, Corey Goodwin, J. Wan, S. Xia, Jianfei Hu, Robert Newman, et al. (2012). (Phosphorylation of the chromatin binding domain of KSHV LANA). (10) 8, pp. 12. PLoS Pathogens.
• Jeannette Delva-Wiley, Israt Jahan, Robert Newman, Lifeng Zhang, Ming Dong (Computational Analysis of the Binding Mechanism of GenX and HSA). (0) 0, pp. null. ACS Omega.
• Lei Cao, Ava Boston, Olugbemiga Jegede, Scott Harrison, Robert Newman, Elimelda Ongeri (Inflammation and kidney injury in diabetic African American men). (https://www.ncbi.nlm.nih.gov/pubmed/30868076) 2019, pp. 2019 Feb 5;2019:5359635. doi: 10.1155/2019/5359635. eCollection 2019.. Journal of diabetes research.