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Patrick McPhail Martin

Interim Associate Dean

Patrick McPhail Martin
College
College of Science and Technology

Department
Biology

Contact
Smith Hall 2002
Education
B.S.Biology / Virginia Union University
Ph.D.Cell Biology / University of Virginia

Bio

The primary research interest focus of my group is to investigate the regulation of malignant brain, breast and prostate tumor formation, metastatic progression as well as developing drugs that effectively inhibit the oncogenic characteristics of tumors. Another research interest is examining the underlying cellular principles of cancers that are more aggressive in African-Americans. Specifically, our research interests are examining why African-American women are disproportionately affected by breast cancers and African American men are diagnosed with prostate cancers that are highly metastatic and resistant to known therapeutic regimens. R

Research Interests

brain and breast tumor research, cancer health disparities, research training education

Recent Publications

  • Antonio Baines, Patrick Martin, Checo Rorie (2016). (Current and Emerging Targeting Strategies for Treatment of Pancreatic Cancer). In Kevin Pruitt, (Molecular and Cellular Changes in the Cancer Cell) 144, pp. 277-320 ).
  • S Beebe, P Cagle, T Edwards, A González-Sarrías, A Holder, A Huddleston, Patrick Martin, S Sandhaus, N Seeram, R Taylor, Y Tse-Dinh, R Venkatraman, R Weber, Y Wooten (2016). (A novel copper(II) complex identified as a potent drug against colorectal and breast cancer cells and as a poison inhibitor for human topoisomerase IIα.). 64, pp. 45-49 ). Inorganic chemistry communications.
  • Patrice Cagle, Camille Cooper, John Durrant, Alvin Holder, William Jarrett, Ping Ji, Robert Johnson, Lesley Lewis-Alleyne, Patrick Martin, Long Nguyen, Melinda Solomon, Don VanDerveer, Jennifer Vital , Jennie Williams (2016). (An in vitro study on the effect of synthesized tin(IV) complexes on glioblastoma, colorectal and skin cancer cell lines.). (1) 1, pp. 7-15 ).
  • Patrick Martin (2014). (contributing author). pp. 880-885 ). Molecular Medicine Reports.
  • P Cagle, E Mahdavian, M Marshall, Patrick Martin, Q Quick, B Salvatore (2014). (Caspase-dependent signaling underlies glioblastoma cell death in response to the fungal metabolite, fusarochromanone.). (3) 34, pp. 880-5 ). International journal of molecular medicine.
  • C Burdsal, I González, T Harris, S Mager, Patrick Martin, J Sloan, A Sutherland (2012). (Leucine and arginine regulate trophoblast motility through mTOR-dependent and independent pathways in the preimplantation mouse embryo.). (2) 361, pp. 286-300 ). Developmental biology.
  • S Aeder, C Chrestensen, I Hussaini, Patrick Martin, T Sturgill (2007). (Phorbol 12-myristate 13-acetate and serum synergize to promote rapamycin-insensitive cell proliferation via protein kinase C-eta.). (3) 26, pp. 407-14 ). Oncogene.
  • S Amos, I Hussaini, Patrick Martin, A Riggan, R Uht (2007). (The protein kinase C-eta isoform induces proliferation in glioblastoma cell lines through an ERK/Elk-1 pathway.). (20) 26, pp. 2885-93 ). Oncogene.
  • S Amos, I Hussaini, Patrick Martin, S Parsons, G Polar (2005). (Phorbol 12-myristate 13-acetate induces epidermal growth factor receptor transactivation via protein kinase Cdelta/c-Src pathways in glioblastoma cells.). (9) 280, pp. 7729-38 ). The Journal of biological chemistry.
  • I Hussaini, Patrick Martin (2005). (PKC eta as a therapeutic target in glioblastoma multiforme.). (2) 9, pp. 299-313 ). Expert opinion on therapeutic targets.
  • S Aeder, I Hussaini, Patrick Martin, J Soh (2004). (PKC-eta mediates glioblastoma cell proliferation through the Akt and mTOR signaling pathways.). (56) 23, pp. 9062-9 ). Oncogene.
  • Patrick Martin, A Sutherland, L Van Winkle (2003). (Amino acid transport regulates blastocyst implantation.). (4) 69, pp. 1101-8 ). Biology of reproduction.
  • Patrick Martin, A Sutherland (2001). (Exogenous amino acids regulate trophectoderm differentiation in the mouse blastocyst through an mTOR-dependent pathway.). (1) 240, pp. 182-93 ). Developmental biology.