Simone M Smith

Research Interests

Enhancing wound healing and tissue regeneration in soft connective tissue (skin and tendon). Very young, healthy tissues heal in a more regenerative manner that is superior to the reparative healing seen in older or diseased tissue. The molecular orchestrators of this regenerative healing are not firmly established. My research will allow for better diagnostic and prognostic indicators of tissue health and better therapeutic intervention to restore tissues to aesthetically and functionally optimal states. The findings will have a substantial benefit to the military, to aged individuals, and to those with chronic wounds, including diabetics.

Recent Publications

• Simone Smith, Joan Marini (2015). (Osteogenesis Imperfecta. ). In De Groot, Beck-Peccoz et. al., Endotext .
• Joan Marini, Simone Smith, Adi Reich (2014). (Osteogenesis Imperfecta due to mutations in non-collagenous genes: Lessons in bone biology.). (4) 26, pp. 500-7. Curr Opin Pediatr..
• Simone Smith, Zhang Guiyun, Birk David (2013). (Collagen V localizes to pericellular sites during tendon collagen fibrillogenesis.). 13, pp. 00119-4. Matrix Biol.
• Simone Smith, Charles Thomas, David Birk (2011). (Pericellular proteins of the developing mouse tendon: a proteomic analysis. ). (1) 53, pp. 2-13. Connect Tissue Res..
• Richard Wenstrup, Simone Smith, Florer Jane, Guiyun Zhang, David Beason, Robert Seegmiller, Louis Soslowsky, David Birk (2011). (Regulation of collagen fibril nucleation and initial fibril assembly involves coordinate interactions with collagens V and XI in developing tendon. ). (23) 286, pp. 20455-65. J Biol Chem..
• Simone Smith, David Birk (2010). (Focus on Molecules: Collagens V and XI.). Exp Eye Res. .
• Simone Smith, Leigh West, John Hassell (2007). (The core protein of growth plate perlecan binds FGF-18 and alters its mitogenic effect on chondrocytes.). 468, pp. 244-251. Arch Biochem Biophys..
• Simone Smith, John Hassell (2006). (Focus on molecules: perlecan (HSPG2).). (3) 83, pp. 471-2. Exp Eye Res..
• Simone Smith, L. West, P. Govindraj, X. Zhang, D. Ornitz, J. Hassell (2006). (Heparan and chondroitin sulfate on growth plate perlecan mediate binding and delivery of FGF-2 to FGF receptors.). (3) 26, pp. 175-184. Matrix Biol..
• Prasanthi Govindraj, Leigh West, Simone Smith, John Hassell (2006). (Modulation of FGF-2 binding to chondrocytes from the developing growth plate by perlecan.). (4) 25, pp. 232-9. Matrix Biol. .