Simone M. Smith

TitleAssistant Professor



OfficeBarnes Hall
Room: G19

1601 East Market Street
Greensboro, NC 27411

Simone M. Smith


Ph D: Medical Sciences, The University of South Florida, 2007

BS: Biology, The University of South Florida, 1998

Research Interests

Enhancing wound healing and tissue regeneration in soft connective tissue (skin and tendon). Very young, healthy tissues heal in a more regenerative manner that is superior to the reparative healing seen in older or diseased tissue. The molecular orchestrators of this regenerative healing are not firmly established. My research will allow for better diagnostic and prognostic indicators of tissue health and better therapeutic intervention to restore tissues to aesthetically and functionally optimal states. The findings will have a substantial benefit to the military, to aged individuals, and to those with chronic wounds, including diabetics.

Recent Publications

Smith,  Simone  Marini,  Joan  ( 2015).  Osteogenesis Imperfecta. .  In De Groot, Beck-Peccoz et. al.    Endotext .

Marini,  Joan  Smith,  Simone  Reich,  Adi  ( 2014).  Osteogenesis Imperfecta due to mutations in non-collagenous genes: Lessons in bone biology..  ( 4,  26,  pp. 500-7).   Curr Opin Pediatr..

Smith,  Simone  Guiyun,  Zhang  David,  Birk  ( 2013).  Collagen V localizes to pericellular sites during tendon collagen fibrillogenesis..  ( 13,  pp. 00119-4).   Matrix Biol.

Smith,  Simone  Thomas,  Charles  Birk,  David  ( 2011).  Pericellular proteins of the developing mouse tendon: a proteomic analysis. .  ( 1,  53,  pp. 2-13).   Connect Tissue Res..

Wenstrup,  Richard  Smith,  Simone  Jane,  Florer  Zhang,  Guiyun  Beason,  David  Seegmiller,  Robert  Soslowsky,  Louis  Birk,  David  ( 2011).  Regulation of collagen fibril nucleation and initial fibril assembly involves coordinate interactions with collagens V and XI in developing tendon. .  ( 23,  286,  pp. 20455-65).   J Biol Chem..

Smith,  Simone  Birk,  David  ( 2010).  Focus on Molecules: Collagens V and XI..    Exp Eye Res. .

Smith,  Simone  West,  Leigh  Hassell,  John  ( 2007).  The core protein of growth plate perlecan binds FGF-18 and alters its mitogenic effect on chondrocytes..  ( 468,  pp. 244-251).   Arch Biochem Biophys..

Smith,  Simone  West,  L.  Govindraj,  P.  Zhang,  X.  Ornitz,  D.  Hassell,  J.  ( 2006).  Heparan and chondroitin sulfate on growth plate perlecan mediate binding and delivery of FGF-2 to FGF receptors..  ( 3,  26,  pp. 175-184).   Matrix Biol..

Smith,  Simone  Hassell,  John  ( 2006).  Focus on molecules: perlecan (HSPG2)..  ( 3,  83,  pp. 471-2).   Exp Eye Res..

Govindraj,  Prasanthi  West,  Leigh  Smith,  Simone  Hassell,  John  ( 2006).  Modulation of FGF-2 binding to chondrocytes from the developing growth plate by perlecan..  ( 4,  25,  pp. 232-9).   Matrix Biol. .