Antoinette M. Maldonado-Devincci

TitleAssistant Professor

DepartmentPsychology

Phone336-285-2273

Emailamdevinc@ncat.edu

Websitehttps://www.ncbi.nlm.nih.gov/sites/myncbi/1HaVgm03xsck7/bibliography/42759200/public/?sort=date&direction=descending

OfficeNew Science Building
Room: 228

1601 East Market Street
Greensboro, NC 27411

Antoinette M. Maldonado-Devincci

Education

Ph D: Psychobiology, University of South Florida , 2011

MA: Psychology, University of South Florida , 2007

BA: Psychology, University of South Florida, 2004


Research Interests

My current research broadly centers around understanding how sex differences that emerge during adolescence impact long-term changes in brain and behavior. I am particularly interested in investigating how binge alcohol exposure during adolescence changes 1) alcohol use disorders, 2) mood disorders, and 3) abnormal brain development in adulthood. This work is accomplished using preclinical animals models of adolescent binge alcohol exposure. I am currently appointed as a Faculty Scholar to the North Carolina Translational and Clinical Sciences Institute through UNC Chapel Hill. My current research projects use a mouse model to determine how sex differences and binge alcohol exposure during adolescence impact long-term changes in 1) brain neurosteroids; 2) affective behaviors; 3) alcohol drinking in adulthood.


Recent Publications

Stevenson,  Rebekah  Hoffman,  Jessica  Maldonado-Devincci,  Antoniette  Faccidomo,  Sara  Hodge,  Clyde  ( 2019).  MGluR5 activity is required for the induction of ethanol behavioral sensitization and associated changes in ERK MAP kinase phosphorylation in the nucleus accumbens shell and lateral habenbula. .  ( 23,  367,  pp. 19-27).   Behavioral Brain Research.

Beattie,  M  Maldonado-Devincci,  Antoinette  Porcu,  P  O'Buckley,  T  Daunais,  J  Grant,  K  Morrow,  A  ( 2017).  Voluntary ethanol consumption reduces GABAergic neuroactive steroid (3α,5α)3-hydroxypregnan-20-one (3α,5α-THP) in the amygdala of the cynomolgus monkey.  ( 2,  22,  pp. 318-330).   Addiction Biology.

Bell,  Richard  Hauser,  Sheketha  Liang,  Tiebing  Sari,  Youssef  Maldonado-Devincci,  Antoinette  Rodd,  Zachary  ( 2017).  Rat Animal Models for Screening Medications to Treat Alcohol Abuse and Dependence.  ( 122,  pp. 201-243).   Neuropharmacology.

Hasirci,  A.  Maldonado-Devincci,  Antoinette  Beattie,  Matthew  O'Buckley,  Todd  Morrow,  A.  ( 2017).  Cellular GABAergic neuroactive steroid (3α,5α)-3-hydroxy-pregnan-20-one (3α,5α-THP) immunostaining levels are increased in the ventral tegmental area of the human Alcohol Use Disorder patient: A postmortem study.  ( 2,  41,  pp. 299-311).   Alcoholism, Clinical and Experimental Research.

Beattie,  Matthew  Maldonado-Devincci,  Antoniette  Cook,  Jason  Morrow,  A.  ( 2016).  The Effects of Acute and Chronic Ethanol Exposure on GABAergic Neuroactive Steroid Immunohistochemistry: Relationship to Ethanol Drinking.  In Victor R. Preedy,  Neuropathology of Drug Addictions and Substance Misuse Volume 1: Foundations of Understanding, Tobacco, Alcohol, Cannabinoids and Opioids    Academic Press.

Maldonado-Devincci,  Antoniette  Kampov-Polevoi,  Alexander  McKinley,  Raechel  Morrow,  Danielle  O’Buckley,  Todd  Morrow,  A.  ( 2016).  Chronic intermittent ethanol exposure alters stress effects on (3α,5α)-3-hydroxy-pregnan-20-one (3α,5α-THP) immunolabeling of amygdala neurons in C57BL/6J mice.  ( 10,  pp. 12).   Frontiers in Cellular Neuroscience.

Pleil,  K  Lowery-Gionta,  E  Crowley,  N  Li ,  C  Marcinkiewcz,  C  Rose,  J  McCall,  N  Maldonado-Devincci,  A  Morrow,  A  Jones,  S  Kash,  T  ( 2015).  Effects of chronic ethanol exposure on neuronal function in the prefrontal cortex and extended amygdala.  ( 99,  pp. 735-49).   Neuropharmacology.

Maldonado-Devincci,  Antoniette  Cook,  J  O'Buckley,  T  Morrow,  D  McKinley,  R  Lopez,  M  Becker,  H  Morrow,  A  ( 2014).  Chronic intermittent ethanol exposure and withdrawal alters (3α,5α)-3-hydroxy-pregnan-20-one immunostaining in cortical and limbic brain regions of C57BL/6J mice.  ( 10,  38,  pp. 2561-71).   Alcoholism, Clinical and Experimental Research.

Maldonado-Devincci,  Antoniette  Beattie,  M  Morrow,  D  McKinley,  R  Cook,  J  O'Buckley,  T  Morrow,  A  ( 2014).  Reduction of circulating and selective limbic brain levels of (3α,5α)-3-hydroxy-pregnan-20-one (3α,5α-THP) following forced swim stress in C57BL/6J mice.  ( 17,  231,  pp. 3281-92).   Psychopharmacology.

Cook,  J  Nelli,  S  Neighbors,  M  Morrow,  D  O'Buckley,  T  Maldonado-Devincci,  Antoniette  Morrow,  A  ( 2014).  Ethanol alters local cellular levels of (3α,5α)-3-hydroxypregnan-20-one (3α,5α-THP) independent of the adrenals in subcortical brain regions.  ( 8,  39,  pp. 1978-87).   Neuropsychopharmacology .

Cook,  J  Werner,  D  Maldonado-Devincci,  Antoniette  Leonard,  M  Fisher,  K  O'Buckley,  T  Porcu,  P  McCown,  T  Besheer,  J  Hodge,  C  Morrow,  A  ( 2014).  Overexpression of the steroidogenic enzyme cytochrome P450 side chain cleavage in the ventral tegmental area increases 3α,5α-THP and reduces long-term operant ethanol self-administration.  ( 17,  34,  pp. 5824-34).   The Journal of Neuroscience : the official journal of the Society for Neuroscience.

Maldonado-Devincci,  Antoniette  Stevens, Jr,  S  Kirstein,  C  ( 2012).  Investigation of age-specific behavioral and proteomic changes in an animal model of chronic ethanol exposure.  ( 829,  pp. 471-85).   Methods in Molecular Biology (Clifton, N.J.).

Maldonado-Devincci,  Antoniette  Alipour,  K  Michael,  L  Kirstein,  C  ( 2010).  Repeated binge ethanol administration during adolescence enhances voluntary sweetened ethanol intake in young adulthood in male and female rats.  ( 4,  96,  pp. 476-87).   Pharmacology, Biochemistry, and Behavior.

Maldonado-Devincci,  Antoniette  Badanich,  K  Kirstein,  C  ( 2010).  Alcohol during adolescence selectively alters immediate and long-term behavior and neurochemistry.  ( 1,  44,  pp. 57-66).   Alcohol (Fayetteville, N.Y.).

Maldonado,  A  Finkbeiner,  L  Kirstein,  C  ( 2008).  Social interaction and partner familiarity differentially alter voluntary ethanol intake in adolescent male and female rats.  ( 8,  42,  pp. 641-8).   Alcohol (Fayetteville, N.Y.).

Maldonado,  A  Finkbeiner,  L  Alipour,  K  Kirstein,  C  ( 2008).  Voluntary ethanol consumption differs in adolescent and adult male rats using a modified sucrose-fading paradigm.  ( 9,  32,  pp. 1574-82).   Alcoholism, Clinical and Experimental Research.

Badanich,  K  Maldonado,  Antoniette  Kirstein,  C  ( 2008).  Early adolescents show enhanced acute cocaine-induced locomotor activity in comparison to late adolescent and adult rats.  ( 2,  50,  pp. 127-33).   Developmental Psychobiology.

Badanich,  Kimberly  Maldonado,  Antoniette  Kirstein,  Cheryl  ( 2007).  Chronic ethanol exposure during adolescence increases basal dopamine in the nucleus accumbens septi during adulthood.  ( 5,  31,  pp. 895-900 ).   Alcoholism, Clinical and Experimental Research.

Maldonado,  Antoniette  Kirstein,  Cheryl  ( 2005).  Cocaine-induced locomotor activity is increased by prior handling in adolescent but not adult female rats.  ( 4,  86,  pp. 568-72).   Physiology & Behavior.

Maldonado,  Antoniette  Kirstein,  Cheryl  ( 2005).  Handling alters cocaine-induced activity in adolescent but not adult male rats.  ( 2,  84,  pp. 321-326).   Physiology and Behavior.