Chemistry Department

			Divi Venkateswarlu, Ph.D. Assistant Professor Computational/Physical Chemistry 338, NSB Tel: (336)433-6711 Fax: (336)334-7124 Email: divi@ncat.edu Visit his personal webpage	back
Education M.Sc. Regional Engineering College, India1988 M.Phil. University of Hyderabad, India 1989 Ph.D. North Eastern Hill University, India, 1996 Experience 2004-present Assistant Professor, Physical/Computational Chemistry, North Carolina A& T State University 1999-2004 Research Associate, University of North Carolina, Chapel Hill, NC 1998-99 Postdoctoral Fellow, University of Minnesota, Minneapolis, MN Research Interests Computational structural biochemistry with emphasis on protein structure, function and macromolecular protein-protein/protein-DNA interactions Current Projects Structural understanding of human blood coagulation proteins (FVIIIa,IXa and FX) and protein-protein complexes (FVIIIa.IXa and FVIIIa.IXa.FX) associated with intrinsic pathway. Structure-based design of sugar-phosphate modified oligonucleotides: Implications for anti-sense and RNA-intereference targeted synthetic oligonucleotides. Selected Publications Lalith Perera, T.A. Darden, Robert E. Duke, Divi Venkateswarlu and Lee G. Pedersen Early Unfolding response of a stable protein domain to environmental changes J. Phys. Chem. A. (2004) 45: 9834-9840 Divi Venkateswarlu, Robert Duke, Lalith Perera, Thomas Darden and Lee G. Pedersen An all-atom solution-equilibrated model for human extrinsic blood coagulation complex (TF.VIIa.Xa): A protein-protein docking and molecular dynamics refinement study J. Thrombosis and Heamostasis (2003) 12:2577-2588 Divi Venkateswarlu, S. Krishnaswamy, Tom Darden and Lee G. Pedersen. Three-dimensional Solution Structure of Tropidechis carinatus venom extract Trocarin: A Structural Homologue of Xa and Prothrombin Activator. J. Mol. Mod. (2002) 8:302-31. Divi Venkateswarlu, Lalith Perera, Tom Darden and Lee G. Pedersen Structure and Dynamics of Zymogenic form of Blood Coagulation Factor X: A Molecular Dynamics Investigation. Biophys. J. (2002) 82:1190 Divi Venkateswarlu and D.M. Ferguson. Effect of C2'-Substitution on Arabinonucleic Acid structure and Conformation. J.Am.Chem.Soc. (1999) 120:5593 Divi Venkateswarlu, K.E. Lind, V. Mohan, M. Manoharan and D.M. Ferguson Structure and Stability of DNA:RNA duplexes containing 2'-O-Methyl and 2'-S-Methyl Oligonucleotides: A Molecular Dynamics Investigation. Nucleic Acid Res. (1999) 27:2189 Divi Venkateswarlu and Jerzy Leszczynski Py*Pu.Py type triplexes with modified bases: Ab initio SCF-MO studies towards improved DNA recognition. J.Phys.Chem-A (1999) 103:3489 Divi Venkateswarlu and Jerzy Leszczynski Tautomeric equilibria in 8-oxopurines: Implication for mutagenecity. J Comp. Aided Mol. Des. (1998) 12:373 back