- Education
- B.S. Baath University, Homs, Syria, 1978
- Ph.D. Northern Illinois University, DeKalb, Illinois 1988
- Experience
- Industrial
- 1978 - 1982, Petroleum Engineer , General Oil Company, Homs, Syria
- Research and Consulting
- 1988 -1990, Postdoctoral Fellow, Department of Chemistry, University of California at Davis. With Professor Gerd N. LaMar.
- 1990-1993, Postdoctoral Fellow, Department of Biochemistry, North Carolina State University. With Professor James D. Otvos.
- 1993-1994, NMR professional consultant, Environmental Protection Agency, Research Triangle Park, NC.
- 1993-1995,Postdoctoral fellow, Department of Biochemistry, North Carolina State University. With Professor Paul F. Agris.
- Summer '98, Department of Biochemistry, North Carolina State University, Visiting Professor.
- Summer '99, Department of Biochemistry, North Carolina State University, Visiting Professor.
- Summer 2000, School of Pharmacy, University of Connecticut at Stores, Visiting Professor.
- Summer 2001, School of Pharmacy, University of Connecticut at Stores, Visiting Professor.
- Teaching and Research
- 1995-2000, Assistant Professor of Chemistry, North Carolina A&T State University, Greensboro, NC
- 2001-, Associate Professor of Chemistry, North Carolina A&T State University, Greensboro, NC
- Research Interests
- The study of structure/function and metal binding of biomolecules by the use of spectroscopy such as UV, fluorescence and NMR.
- The study of structure/function of a number of synthetic compounds as prospective treatment for cocaine addiction by the use of spectroscopy such as UV, fluorescence and NMR.
- Current Projects
- In the process of studying a number of metal ions binding properties to several modified uridines and modified-uridines-containing short oligonucleotides.
- Determining the three-dimensional structures of two compounds, that were shown to have activity that render them to be prospect treatment for cocaine addiction, in chloroform and in lipid solutions by NMR and molecular modeling.
- Selected Publications
- Delnomdedieu, M.; M. M. Basti; J. D. Otvos; and D. J. Thomas; "Transfer of Arsenite from Glutathione to Dithiols, A Model of Interaction"; Chem. Res. Toxicol., 6 no. 5 598 (1993).
- Otvos, J. D., X. Liu, H. Li, G. Shen, and M. Basti; "Dynamic Aspects of Metallothionein Structure", Metallothionein III, Biological Roles and Medical Implications, 57 (1993).
- Delnomdedieu, M.; M. M. Basti; J. D. Otvos; and D. J. Thomas; "Reduction and Binding of Arsenate and Dimethylarsinate by Glutathione: A Magnetic Resonance Study". Chem. Biol. Interact., 90 no. 2 139 (1994).
- Wu, Y; M. M. Basti; A. Gambacurta; E. Chiancone; F. Ascoli; and G. N. Lamar "Proton-NMR Investigation of the Heme Activity in the Cynaomet Derivative of the Cooperative Homodimeric Hemoglobin from Scapharca Inaequivalvis", Biochem. Biophys. Acta. 1298 261(1996).
- Agris P. F., M. M. Basti, J. W. Stuart, and R. Guenther "NMR and Paramagnetic Ion Substitution Locates a Modified-Nucleoside Dependent Metal Binding Site in DNA: Molecular Dynamics, Surface Charge and H2O Ordering"; Magn. Reson. Chem. 34 87(1996).
- Agris, P. F.; V. Dao; M. M. Basti ; and R. Guenther "Ribosome-independent Anticodon-codon Binding: Roles of Base Modifications and Mg+2"; Biospectroscopy 2 205(1996).
- Stuart, J. W.; M. M. Basti; H. Sierzputowska-Gracz; R. Guenther; and P. F. Agris; "Solution Structure of a Mg+2-bound RNA trinucleotide D-acp3 U-A as Determined by NMR and Molecular Dynamics"; Nucleosides and Nulcleotides, 15 no.5, 1009 (1996).
- Basti, M. M.; J. W. Stuart; Anh Lam, R. Guenther; and P. F. Agris; "Three dimensional Structure of the Biologically Active DNA analogue of the Yeast tRNAPheAC as Derived from High Resolution NMR"; Nature Structural Biology, 3, 38, (1996).
- Yarian, C. S., Basti, M.M., Cain, R., Ansari, G., Guenther, R.H., Sochacka, E., Czerwinska, G., Malkiewicz, A. and Agris, P.F. (1999) Structural and functional roles of the N1- and N3-protons of PseudoUridine at tRNA's position 39. Nucl. Acids Res.27:3543-3549.
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