Robert H. Newman

TitleAssistant Professor

DepartmentBiology

Phone336-285-2189

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Emailrhnewman@ncat.edu

OfficeBarnes Hall
Room: 105

1601 East Market Street
Greensboro, NC 27411

Robert H. Newman

Education

Ph D: Biochemistry and Molecular Biology, Johns Hopkins University, 2007

BA: Biology and Biochemistry, McDaniel College, 1999


Research Interests

In the Newman laboratory, we are interested in understanding the organization and regulation of cellular signaling pathways, with a particular emphasis on phosphorylation-dependent signaling pathways mediated by protein kinases and phosphatases. Research in the lab is organized around two central questions: 1) which cellular proteins are phosphorylated by a given kinase under physiological conditions and 2) how are specific kinases and phosphatases—and ultimately the signaling networks of which they are a part—regulated within the native cellular environment? To answer these questions, we take a two-pronged approach based on 1) systems-level analysis of kinase-substrate relationships (KSRs) and the biochemical factors underlying kinase substrate selection and 2) the development and application of genetically-targetable fluorescence resonance energy transfer (FRET)-based biosensors designed to study the spatiotemporal regulation of kinase activity within the endogenous cellular environment.


Recent Publications

Ismail, H  Newman, Robert  Kc, Dukka  (2016).  RF-Hydroxysite: a random forest based predictor for hydroxylation sites..  (8,  12,  pp. 2427-35).  Molecular bioSystems.

Ismail, H  Jones, Adri-Anne  Kim, Jung  Newman, Robert  Kc, Dukka  (2016).  RF-Phos: A Novel General Phosphorylation Site Prediction Tool Based on Random Forest..  (2016,  pp. 3281590).  BioMed research international.

Woodard, Crystal  Liao, G  Goodwin, Corey  Hu, Jianfei  Dos Reis, T  Newman, Robert  Rho, Heesool  Qian, Jiang  Zhu, Heng  Hayward, S  (2015).  A Screen for ERK Primed GSK-3 Substrates Identifies the p53 Inhibitor iASPP.  (pub ahead of print,  pp. pii: JVI.01072-15).  J. Virol.

Wu, X.  Renuse, S.  Sahasrabuddhe, N.  Zahari, M.  Chaerkady, R.  Kim, M.  Newman, Robert  Zhu, H.  Vogelstein, B.  Park, B.  Pandey, A.  (2014).  Activation of diverse signaling pathways by oncogenic PIK3CA mutations.  (5,  pp. 4961-4989).  Nature Communications.

Newman, Robert  (2014).  Global analysis of phosphorylation networks in humans.  (1844,  ).  Biochemica Biophysica Acta-Proteins and Proteomics/Elsevier.