Dr. Shengmin Sang

Dr. Shengmin Sang

CONTACT INFORMATION:

Office: Suite 4222, UNC Nutrition Research Building, NCRC, 500 Laureate Way, Kannapolis, NC 28081
Phone: (704) 250-5710
Fax: (704) 250-5709
email: ssang@ncat.edu

EDUCATION:

  • 1994 B.S., Shandong Normal University
  • 1999 Ph.D., Shanghai Institute of Materia Medica, Chinese Academy of Sciences

AREAS OF EXPERTISE:

  • Metabolomics and dietary exposure biomarkers in cancer prevention research.
  • Bioavailability and biotransformation studies of bioactive natural products in animals and humans.
  • Development of new chemopreventive agents from dietary sources using in vitro and animal models.
  • Mechanistic studies of bioactive food components on oxidative stress (keap1/Nrf2/ARE pathway) and carbonyl stress (Advanced Glycation End Products (AGEs) for the prevention of diabetic complications).
  • Purification and structure determination of bioactive components from herbal medicine and functional foods.
  • Standardization and quality control of herbal medicine and functional foods.

RESEARCH DESCRIPTION / CURRENT RESEARCH:

Colon Cancer prevention

  • The impact of microbiota on the chemopreventive effects of black tea polyphenols in colitis-associated colon cancer
  • Wheat bran for colon cancer prevention: A targeted metabolomic approach
  • Aspirinated phytochemicals as novel chemopreventive agents for colon cancer
  • Bioactive ginger components for colitis-associated colon cancer prevention

Obesity and diabetes

  • Dietary flavonoids as reactive carbonyl scavengers to prevent the development of diabetic complications
  • Bioactive food compounds from ginger, tea and apple with applications in prevention/management of diabetes and obesity
  • Bioactive phytochemicals in whole grains for prevention/management of metabolic syndrome
  • Carnosic acid enriched rosemary extract and its active components reduce weight gain and type 2 diabetes

 

PUBLICATIONS

(Selected from over 200 publications; full publication list and citation)

  1. Zhu, Y.; Zhao, Y.; Wang, P.; Ahmedna, M.; Sang, S. Bioactive ginger constituents alleviate protein glycation by trapping methylglyoxal. Chem. Res. Toxicol. 2015, 28 (9), 1842-1849.
  2. Fu, J.; Zhu, Y.; Yerke, A.; Wise, M.; Johnson, J.; Chu, Y.; Sang, S. Oat avenanthramides induce heme oxygenase-1 expression via Nrf2-mediated signaling in HK-2 cells. Mol Nutr Food Res. 2015 (In press).
  3. Zhu, Y.; Fu, J.; Shurlknight, K.L.; Soroka, D.N.; Hu, Y.; Chen, X.; Sang, S. Novel Resveratrol-based Aspirin Prodrugs: Synthesis, Metabolism, and Anticancer Activity. J. Med. Chem. 2015, 58(16), 6494-506.
  4. Zhao, Y.; Sedighi, R.; Wang, P.; Chen, H.; Zhu, Y.; Sang, S. Carnosic acid as the major bioactive component in rosemary extract ameliorates high-fat diet-induced obesity and metabolic syndrome in mice. J. Agric. Food Chem. 2015, 63(19), 4843-4852.
  5. Zhu, Y.; Zhao, Y.; Wang, P.; Ho, C.T.; Ahmedna, M.; Sang, S. Tea Flavanols Block Advanced Glycation of Lens Crystallins Induced by Dehydroascorbic Acid. Chem. Res. Toxicol. 2015, 28 (1), 135-143.
  6. Zhu, Y.; Soroka, D.N.; Sang, S. Oxyphytosterols as Active Ingredients in Wheat Bran Suppress Human Colon Cancer Cell Growth: Identification, Chemical Synthesis and Biological Evaluation. J. Agric. Food Chem. 2015, 63(8), 2264-2276.
  7. Sedighi, R.; Zhao, Y.; Yerke, A.; Sang, S. Preventive and Protective Properties of Rosemary (Rosmarinus Officinalis L.) in Obesity and Diabetes Mellitus of Metabolic Disorders: A Brief Review. Current Opinion in Food Science 2015, 2, 58-70.
  8. Wang, P.; Chen, H.; Zhu, Y.; McBride, J.; Fu, J.; Sang, S. Oat avenanthramide-C (2c) is metabolized by mice and the human microbiota into bioactive metabolites. J Nutr. 2015, 145 (2), 239-245.
  9. Li, X.; Zheng, T.; Sang, S.; Lv, L. Quercetin Inhibits Advanced Glycation End Product Formation by Trapping Methylglyoxal and Glyoxal. J. Agric. Food Chem. 2014, 62(50), 12152-12158.
  10. Lei, L.; Liu, Y.; Wang, X.; Jiao, R.; Ma, K.Y.; Li, Y.M.; Wang, L.; Man, S.W.; Sang, S.; Huang, Y.; Chen, Z.Y. Plasma cholesterol-lowing activity of gingerols- and shogaols-riched extract is mediated by increasing sterol excretion. J. Agric. Food Chem. 2014, 62(43), 10515-10521.
  11. Chen, H.; Fu, J.; Chen, H.; Hu, Y.; Soroka, D.N.; Prigge, J.R; Schmidt, E.E.; Major, M.B.; Chen, X.; and Sang, S. Ginger compound [6]-shogaol and its cysteine-conjugated metabolite (M2) activate Nrf2 in colon epithelial cells in vitro and in vivo. Chem. Res. Toxicol. 2014, 27(9), 1575-1585.
  12. Fu, J.; Chen, H.; Soroka, D.N.; Warin, R.F.; Sang, S. Cysteine-conjugated metabolites of ginger components shogaols induce apoptosis through oxidative stress-mediated p53 pathway in human colon cancer cells. J. Agric. Food Chem.  2014, 62(20), 4632-4642.
  13. Shao, X.; Chen, H.; Zhu, Y.D.; Seldighi, R.; Ho, C.T.; Sang, S. Essential Structural Requirements and Additive Effects for Flavonoids to Scavenge Methylglyoxal. J. Agric. Food Chem. 2014, 62(14), 3202-3210.
  14. Warin, R.F.; Chen, H.; Soroka, D.N.; Zhu, Y.; Sang, S. Induction of lung cancer cell apoptosis through the p53 transcription-independent pathway by [6]-shogaol and its cysteine-conjugated metabolite M2. J. Agric. Food Chem. 2014, 62(6), 1352-1362.
  15. Sang, S. Bioavailability and metabolism of bioactive food components. J. Funct. Foods 2014, 7, 1-2.
  16. Chen, H.; Sang, S. Biotransformation of tea polyphenols by gut microbiota. J. Funct. Foods 2014, 7, 26-42.
  17. Zhu, Y.; Shurlknight, K.L.; Chen, X.; Sang, S. Identification and pharmacokinetics of novel alkylresorcinol metabolites in human urine: new candidate biomarkers for whole grain wheat and rye intake. J Nutr. 2014, 144 (2), 114-122.
  18. Maness, L.; Goktepe, I.; Chen, H.; Ahmedna, M.; Sang, S. Impact of phytolacca americana extracts on gene expression of colon cancer cells. Phytother Res. 2014, 28(2), 219-223.
  19. Chen, H.; Soroka, D.N.; Haider, J.; Ferri-Lagneau, K.F.; Leung, T.; Sang, S. [10]-Gingerdiols as the major metabolites of [10]-gingerol in zebrafish embryos and in humans and their hematopoietic effects in zebrafish embryos. J. Agric. Food Chem. 2013, 61(22), 5353-5360.
  20. Chen, H.; Shurlnight, K.; Leung, T.; Sang, S. Cysteine-conjugated metabolite of ginger component [6]-shogaol serves as a carrier of [6]-shogaol in cancer cells and in mice. Chem. Res. Toxicol. 2013, 26(6), 976-985.
  21. Chiou, Y.S.; Sang, S.; Cheng, K.H.; Ho, C.T.; Wang, Y.J.; Pan, M.H. Peracetylated (-)-epigallocatechin-3-gallate (AcEGCG) potently prevents skin carcinogenesis by suppressing the PKD1-dependent signaling pathway in CD34+ skin stem cells and skin tumors. Carcinogenesis, 2013, 34(6), 1315-1322.
  22. Zhu, Y.; Soroka, D.; Sang, S. Structure Elucidation and Chemical Profile of Sphingolipids in Wheat Bran and Their Cytotoxic Effects against Human Colon Cancer Cells. J. Agric. Food Chem. 2013, 61(4), 866-874.
  23. Zhu, Y.; Warin, R.; Soroka, D.; Chen, H.; Sang, S. Metabolites of Ginger Component [6]-Shogaol Remain Bioactive in Cancer Cells and Have Low Toxicity in Normal Cells: Chemical Synthesis and Biological Evaluation. PLoS ONE 2013, 8(1), e54677.
  24. Chen, H.; Soroka, D.; Hu, Y.; Chen, X.; Sang, S. Characterization of Thiol-conjugated Metabolites of Ginger Components Shogaols in Mouse and Human Urine and Modulation of the Glutathione Levels in Cancer Cells by [6]-Shogaol. Mol Nutr Food Res. 2013, 57 (3), 447-458.
  25. Chen, H.; Soroka, D.; Zhu, Y.; Sang, S. Metabolism of Ginger Component [6]-Shogaol in Liver Microsomes from Mouse, Rat, Dog, Monkey, and Human. Mol Nutr Food Res. 2013, 57 (5), 865-876.
  26. Chen, H.; Saeed, H.; Guzman, J.R.; Gillitt, N.D.; Ibrahim, S.A.; Jobin, C.; Sang, S. The microbiota is essential for the generation of black tea theaflavins-derived metabolites. PLoS ONE 2012, 7(12), e51001.
  27. Lv, L.; Chen, H.; Soroka, D.; Chen, X.; Leung, T.; Sang, S. 6-Gingerdiols as the major metabolites of 6-gingerol in cancer cells and in mice and their cytotoxic effects on human cancer cells. J. Agric. Food Chem. 2012, 60(45), 11372-7.
  28. Chen, H.; Shurlnight, K.; Leung, T.; Sang, S. Strucutural identification of theaflavin trigallate and tetragallate from black tea using liquid chromatography/electrospray ionization tandem mass spectrometry. J. Agric. Food Chem. 2012, 60(43), 10850-7.
  29. Chen, H.; Sang, S. Identification of phase II metabolites of thiol-conjugated [6]-shogaol in mouse urine using high-performance liquid chromatography tandem mass spectrometry. J. Chromatogr B. 2012, 907, 126-139.
  30. Zhu, Y.; Soroka, D.; Sang, S. Synthesis and inhibitory activities against colon cancer cell growth and proteasome of alkylresorcinols. J. Agric. Food Chem. 2012, 60(35), 8624-31.
  31. Chen, X.; Zhang, X.; Lu, Y.; Shim, J.Y.; Sang, S.; Sun, Z.; Chen, X. Chemoprevention of 7,12-dimethylbenz[a]anthracene (DMBA)-induced hamster cheek pouch carcinogenesis by a 5-lipoxygenase inhibitor, garcinol. Nutr Cancer 2012, 64(8), 1211-8.
  32. Ferri-Lagneau, K.F.; Moshal, K.S.; Grimes, M.; Zahora, B.; Lv, L.; Sang, S.; Leung, T. Ginger stimulates hematopoiesis via bmp signaling pathway in zebrafish. PLoS ONE, 2012, 7(6), e39327.
  33. Chiou, Y.S.; Ma, N.J.; Sang, S.; Ho, C.T.; Wang, Y.J.; Pan, M.H. Peracetylated (-)-epigallocatechin-3-gallate (AcEGCG) potently suppresses dextran sulfate sodium-induced colitis and colon tumorigenesis in mice. J. Agric. Food Chem. 2012, 60(13), 3441-3451.
  34. Chen, H.; Lv, L.; Soroka, D.; Warin, R.F.; Parks, T.A.; Hu, Y.; Zhu, Y.; Chen, X.; Sang, S. Metabolism of [6]-shogaol in mice and in cancer cells. Drug Metab. Dispos. 2012, 40(4), 742-753.
  35. Chen, H.; Parks, T.A.; Chen, X.; Gillitt, N.; Jobin, C.; Sang, S. Structural identification of mouse fecal metabolites of theaflavin 3, 3'-digallate using liquid chromatography tandem mass spectrometry. J. Chromatogr A. 2011, 1218, 7297-7306.
  36. Zhu, Y.; Conklin, D.; Chen, H.; Wang, L.; Sang, S. 5-Alk(en)ylresorcinols as the major active components in wheat bran inhibit human colon cancer cell growth. Bioorg. Med. Chem. 2011, 19(13), 3973-3982.
  37. Lv, L.S.; Shao, X.; Chen, H.; Ho, C.T.; Sang, S. Genistein inhibits advanced glycation end products formation by trapping methylglyoxal. Chem. Res. Toxicol.  2011, 24(4), 579-586.
  38. Lv, L.S.; Chen, H.; Ho, C.T.; Sang, S. Chemical Components of the Roots of Noni and Their Cytotoxic Effects. Fitoterapia 2011, 8(4), 704-708.
  39. Sang, S.; Lambert, J.D.; Ho, C.T.; Yang, C.S. The chemistry and biotransformation of tea constituents. Pharm. Res. 2011, 64, 87-99.
  40. Shao, X.; Lv, L.; Parks, T.; Wu, H.; Ho, C.T.; Sang, S. Quantitative analysis of ginger components in commercial products using liquid chromatography with electrochemical array detection.  J. Agric. Food Chem. 2010, 58(24), 12608-12614.
  41. Ibarra, A.; Bai, N.S.; He, K.; Bily, A.; Cases, J.; Roller, M.; Sang, S. Fraxinus excelsior seed extract FraxiPure™ limits weight gain and hyperglycemia in high-fat diet induced obese and diabetic mice. Phytomedicine 2010, 18(6), 479-486.
  42. Lambert, J.D.; Sang, S.; Hong, J.; Yang, C.S. Anticancer and anti-inflammatory effects of cysteine metabolites of the green tea polyphenol, (-)-epigallocatechin-3-gallate. J. Agric. Food Chem. 2010 58(18), 10016-10019.
  43. Shao, X.; Chen, X.; Badmaev, V.; Ho, C.T.; Sang, S. Structural identification of mouse urinary metabolites of pterostilbene using liquid chromatography tandem mass spectrometry. Rapid Commun Mass Spectrom 2010, 24(12), 1770-1778.
  44. Wu, H.; Hsieh, M.C.; Lo, C.Y.; Liu, C.B.; Sang, S.; Ho, C.T.; Pan, M.H. 6-Shogaol is more effective than 6-gingerol and curcumin in inhibiting 12-O-tetradecanoylphorbol-13-acetate-induced tumor promotion in mice. Mol Nutr Food Res. 2010, 54(9), 1296-1306.
  45. Shieh, P.C.; Chen, Y.O.; Kuo, D.H.; Chen, F.A.; Tsai, M.L.; Chang, I.S.; Wu, H.; Sang, S.; Ho, C.T.; Pan, M.H. Induction of apoptosis by [8]-shogaol via reactive oxygen species generation, glutathione depletion, and caspase activation in human leukemia cells. J. Agric. Food Chem. 2010, 58 (6), 3847-3854.
  46. Lv, L.S.; Shao, X.; Wang, L.Y.; Huang, D.R.; Ho, C.T.; Sang, S. Stilbene glucoside from Polygonum multiflorum Thunb: A novel natural inhibitor of advanced glycation end products formation by trapping of methylglyoxal. J. Agric. Food Chem. 2010, 58 (4), 2239-2245.
  47. Lambert, J.D.; Kennett, M.J.; Sang, S.; Reuhl, K.R.; Ju, J.; Yang, C.S. Hepatotoxicity of High Oral Dose (-)-Epigallocatechin-3-Gallate in Mice. Food Chem Toxicol. 2010, 48, 409-416.

 

HONORS / AWARDS:

  • 2014, Intellectual Property Award, N.C. A&T’s School of Agriculture and Environmental Sciences
  • 2012, Outstanding Junior Researcher Award, N.C. A&T’s School of Agriculture and Environmental Sciences
  • 2011, Fellow Award, ACS Division of Agricultural and Food Chemistry
  • 2011, Young Investigator Award, The 2011 International Conference on Food Factors
  • 2011, Incentive Award, The United Soybean Board’s Soy Health Research Program
  • 2009, Matthew Suffness Young Investigator Award, The American Society of Pharmacognosy (ASP)
  • 2007, Young Scientist Award, ACS Division of Agricultural and Food Chemistry
  • 2007, Travel award, Fourth International Scientific Symposium on Tea and Human Health
  • 1999, The P&G scholarship, Shanghai Institute of Materia Medica C. A. S.
  • 1998, First-class scholarship, Shanghai Institute of Materia Medica C. A. S.
  • 1997, Second-class scholarship, Shanghai Institute of Materia Medica C. A. S.
  • 1995, Third-class scholarship, Shanghai Institute of Materia Medica C. A. S.
  • 1993, First-class scholarship, Shandong Normal University

 

PROFESSIONAL & SERVICE ACTIVITIES:

Editorial Board:

  • Journal of Agricultural and Food Chemistry
  • Journal of Functional Foods
  • Open Journal of Medicinal Chemistry
  • The Open Natural Products Journal
  • Journal of Chromatography and Separation Techniques
  • E-Journal of Chemistry 

Guest Editor

  • (Journal of Functional Foods): Special issue: Bioavailability and Metabolism of Functional Food Bioactives 

Member in the following professional societies

  • American Chemical Society (ACS)
  • American Society for Nutrition (ASN)
  • The American Association for Cancer Research (AACR)
  • The American Society of Pharmacognosy (ASP)
  • Institute of Food Technologists (IFT)

EDITED Book

Wang, M.F.; Sang, S.; Hwang, L.; Ho, C.T. (Editors) "Herbs: Challenges in Chemistry & Biology", Published by American Chemical Society (February 2006). ISBN 0841239304.

 

Organized Symposiums

  1. "The Chemistry Behind Health Effects of Whole Grains" 252th ACS National Meeting, Philadelphia, PA, August 21-25, 2016. Organizers: Sang, S. and Landberg, R.
  2. "Metabolites & Metabolomics of Food Bioactives & Influence of Gut Microbiota: Chemistry & Health Effects" 250th ACS National Meeting, Boston, MA, August 16-20, 2015. Organizers: Sang, S. and Shahidi, F.
  3. "Physicochemical Properties and Biological Functionality of Oats" 247th ACS National Meeting, Dallas, TX, March 16-20, 2014. Organizers: Sang, S. and Chu, Y.F.
  4.  “Bioavailability and Biotransformation of Nutraceuticals” 2012 Annual Conference of Functional Foods, Nutraceuticals, Natural Health Products, and Dietary Supplements, Hawaii, December 2-6, 2012. Organizers: Sang, S. and Ho, C.T.
  5.  “Reactive Carbonyl Species: Dietary Sources and Health Consequences” 239th ACS National Meeting, San Francisco, CA, March 21-25, 2010. Organizers: Sang, S.; Wang, M.F.; Ho, C.T.; and Yen, G.C.
  6. "Challenges in Chemistry and Biology of Herbs" 227th ACS National Meeting, Anaheim, LA, March 28-April 1, 2004. Organizers: Wang, M.F.; Sang, S.; Hwang,L.; Ho, C.T.