N.C. A&T

Donghui Zhu, Ph.D.

Assistant Professor
Chemical, Biological and Bioengineering
Contact: 329 McNair Hall
Email: dzhu@ncat.edu
Ph: (336) 334-7564 ext. 464
Fax: (336) 334-7904

Education

PhD, Biomedical Engineering, University of Missouri-Columbia
MS, Biomedical Engineering, Washington University in St. Louis
MS, Chemical Engineering, Florida State University
BS, Biochemical Engineering, East China University of Science & Technology

Research Interest

Biomaterials and Biocompatibility
Brain Vascular Biology
Drug discovery and drug delivery
Neurodegenerative diseases
Wound care

Selected Publications

Zhu D, Wang Y, Bell R, et al. Protein S controls hypoxic/ischemic blood-brain barrier disruption through the Tyro3-dependent cross-activation of sphingosine 1-phosphate receptor, Blood, 115, 4963-4972, 2010.
Zhu D, Hu C, Sheng W, et al. NADPH oxidase-mediated reactive oxygen species production alters astrocyte membrane molecular order via phospholipase A2. Biochemical Journal, 421: 201-210, 2009.
Hicks JB, Lai Y, Sheng W, Zhu D, et al. Amyloid-beta peptide induces temporal membrane biphasic changes in astrocytes through cytosolic phospholipase A2. BBA-Biomembranes, 1178: 2512-2519, 2008.
Zhu D, Haidekker MA, Lee JS, et al. Application of Molecular Rotors to the Determination of the Molecular Weight-Dependence of Viscosity in Polymer Melts. Macromolecules, 40: 7730-7732, 2007.
Zhu D. Mathematical modeling of blood coagulation cascade: kinetics of intrinsic and extrinsic pathways in normal and deficient conditions. Blood Coagulation and Fibrinolysis, 18: 637-646, 2007.
Zhu D, Lai Y, Shelat PB, et al. Phospholipases A2 mediate Alzheimer’s A?-induced mitochondrial dysfunction. Journal of Neuroscience, 26: 11111-11119, 2006.
Zhu D, Lennon SP, Peters MH, et al. Brownian diffusion and surface kinetics of liposome and viral particle uptake by human lung cancer cells in-vitro. Annals of Biomedical Engineering, 34: 1573-1586, 2006.
Zhu D, Tan KS, Zhang X, et al. Hydrogen peroxide alters membrane and cytoskeleton properties and enhances intercellular connections in astrocytes. Journal of Cell Science, 118: 3695-3703, 2005.
Wei D, Li J, Zhu D, et al. Synthesis and purification of a novel DNA intercalator-oligonucleotide conjugate. International Journal of Biochromatography, 6: 87-94, 2001.
Qian X, Wei D, Zhu D, et al. Interaction of naphthyl heterocycles with DNA: effects of thiono and thio groups. Journal of the Chemical Society-Perkin Transactions 2, 4: 715-718, 2000.
Huang T, Zhu D, et al. General synthesis of thioxo-1, 8-naphthalimides via thioxo-1, 8-naphthalic anhydrides. Synthesis, 7: 1109-1111, 1999.
Li J, Wei D, Zhu D, et al. Inhibition of multidrug resistance in human tumor cell by naphthyl imide-conjugated anti-sense oligonucleotide. Chinese Journal of Cancer, 20: 373-378, 2001.
Li J, Wei D, Zhu D, and Zhang Y. Synthesis of oligonucleotide-DNA Intercalator Conjugates. Chinese Journal of Pharmaceuticals, 31: 559-563, 2000.
Zhu D, and Wei D. Study of second generation of anti-sense oligonucleotide. Progress in Pharmaceuticals Sciences, 23: 9-13, 1999.
Books: Zhu D. Astroglial cells are not just bystanders in Alzheimer’s, ISBN 9783838330914, 2010.

Professional Referee Activities

Reviewer:
Journal of Neurochemistry, Neurological Sciences, The American Journal of the Medical Sciences, Antioxidants & Redox Signaling, Cell Biology and Toxicology, International Journal of Biochemistry & Cell Biology, Journal of Carcinogenesis, Cancer Letters, Journal of Neurogenetics, Journal of Cellular and Molecular Medicine, Southern Medical Journal
Editorial Board:
Chinese Journal of Cancer
Professional Associations
Sigma Xi, American Society for Neurochemistry, Society for Neuroscience, Biophysical Society, Biomedical Engineering Society

Academic
Athletic
Arts

The College of Engineering ranks No. 1 for the number of degrees awarded to African Americans
U.S. News and World Report ranks the COE in the top third of the Best Undergraduate Engineering Programs
N.C. A&T is the home of the National Science Foundation Engineering Research Center (ERC)
SAES brought in more than $20 million in research grant funding
The School of Agriculture and Environmental Sciences (SAES) is the largest among the nation’s HBCUs
F.D. Bluford Library is one of the region's premier research libraries
The Master of Science in Information (MSIT) Online Program is ranked No. 7 by U.S. News & World Report

A&T had ninety-eight student athletes earn a cumulative 3.0 grade point average or higher for the 2011-2012 academic year
Freshmen Janay Ferrell placed seventh at the Robert Shumke HBCU Classic
Track and Field sprinter Jarrell Elliott qualified for the Olympic trials
Aggie baseball player Xavier Macklin was drafted in the 12th round of the 2011 Major League Baseball Draft
Aggies will host the 2013 Junior National Olympics
N.C. A&T long jumper Shakia Forbes became the first Aggie female to earn All-American honors in a field event
North Carolina A&T has had 16 players drafted to the major leagues

The College of Arts and Sciences awards one-third of the university’s degrees each year
University Choir has performed for President Obama at the White House
The Music Program has been fully accredited by the National Association of Schools of Music since 1991
A&T Jazz Ensemble to release its first professional CD - Jazz Preeminence
Theatre program to perform at the regionally acclaimed "Center Stage Theatre" in Baltimore, Maryland
A&T Lyceum Series brings provocative, culturally diverse programming to the campus and community
Travis W. Alexander has been named National Conductor for the 105 Voices Of History National Concert Choir