Donghui Zhu, Ph.D.

Assistant Professor
Chemical, Biological and Bioengineering
Contact: 329 McNair Hall
Email: dzhu@ncat.edu
Ph: (336) 334-7564 ext. 464
Fax: (336) 334-7904

Education

PhD, Biomedical Engineering, University of Missouri-Columbia
MS, Biomedical Engineering, Washington University in St. Louis
MS, Chemical Engineering, Florida State University
BS, Biochemical Engineering, East China University of Science & Technology

Research Interest

  • Biomaterials and Biocompatibility
  • Brain Vascular Biology
  • Drug discovery and drug delivery
  • Neurodegenerative diseases
  • Wound care

Selected Publications

  • Zhu D, Wang Y, Bell R, et al. Protein S controls hypoxic/ischemic blood-brain barrier disruption through the Tyro3-dependent cross-activation of sphingosine 1-phosphate receptor, Blood, 115, 4963-4972, 2010.
  • Zhu D, Hu C, Sheng W, et al. NADPH oxidase-mediated reactive oxygen species production alters astrocyte membrane molecular order via phospholipase A2. Biochemical Journal, 421: 201-210, 2009.
  • Hicks JB, Lai Y, Sheng W, Zhu D, et al. Amyloid-beta peptide induces temporal membrane biphasic changes in astrocytes through cytosolic phospholipase A2. BBA-Biomembranes, 1178: 2512-2519, 2008.
  • Zhu D, Haidekker MA, Lee JS, et al. Application of Molecular Rotors to the Determination of the Molecular Weight-Dependence of Viscosity in Polymer Melts. Macromolecules, 40: 7730-7732, 2007.
  • Zhu D. Mathematical modeling of blood coagulation cascade: kinetics of intrinsic and extrinsic pathways in normal and deficient conditions. Blood Coagulation and Fibrinolysis, 18: 637-646, 2007.
  • Zhu D, Lai Y, Shelat PB, et al. Phospholipases A2 mediate Alzheimer’s A?-induced mitochondrial dysfunction. Journal of Neuroscience, 26: 11111-11119, 2006.
  • Zhu D, Lennon SP, Peters MH, et al. Brownian diffusion and surface kinetics of liposome and viral particle uptake by human lung cancer cells in-vitro. Annals of Biomedical Engineering, 34: 1573-1586, 2006.
  • Zhu D, Tan KS, Zhang X, et al. Hydrogen peroxide alters membrane and cytoskeleton properties and enhances intercellular connections in astrocytes. Journal of Cell Science, 118: 3695-3703, 2005.
  • Wei D, Li J, Zhu D, et al. Synthesis and purification of a novel DNA intercalator-oligonucleotide conjugate. International Journal of Biochromatography, 6: 87-94, 2001.
  • Qian X, Wei D, Zhu D, et al. Interaction of naphthyl heterocycles with DNA: effects of thiono and thio groups. Journal of the Chemical Society-Perkin Transactions 2, 4: 715-718, 2000.
  • Huang T, Zhu D, et al. General synthesis of thioxo-1, 8-naphthalimides via thioxo-1, 8-naphthalic anhydrides. Synthesis, 7: 1109-1111, 1999.
  • Li J, Wei D, Zhu D, et al. Inhibition of multidrug resistance in human tumor cell by naphthyl imide-conjugated anti-sense oligonucleotide. Chinese Journal of Cancer, 20: 373-378, 2001.
  • Li J, Wei D, Zhu D, and Zhang Y. Synthesis of oligonucleotide-DNA Intercalator Conjugates. Chinese Journal of Pharmaceuticals, 31: 559-563, 2000.
  • Zhu D, and Wei D. Study of second generation of anti-sense oligonucleotide. Progress in Pharmaceuticals Sciences, 23: 9-13, 1999.
  • Books: Zhu D. Astroglial cells are not just bystanders in Alzheimer’s, ISBN 9783838330914, 2010.

Professional Referee Activities

Reviewer:
Journal of Neurochemistry, Neurological Sciences, The American Journal of the Medical Sciences, Antioxidants & Redox Signaling, Cell Biology and Toxicology, International Journal of Biochemistry & Cell Biology, Journal of Carcinogenesis, Cancer Letters, Journal of Neurogenetics, Journal of Cellular and Molecular Medicine, Southern Medical Journal
Editorial Board:
Chinese Journal of Cancer
Professional Associations
Sigma Xi, American Society for Neurochemistry, Society for Neuroscience, Biophysical Society, Biomedical Engineering Society
Points of Pride